camp receptors การใช้

There are also several sets of repeats, sequences resembling the Sp1 transcription factor binding site, and two cAMP receptor binding sites upstream of the cap.
They are believed to have evolved from the cAMP receptor family, arising approximately 1275 million years ago before the split of Unikonts from a common ancestor.
In an environment with a low glucose concentration, cAMP accumulates and binds to the allosteric site on CRP ( cAMP receptor protein ), a transcription activator protein.
First discovered in Gram-negative bacteria, both Cyclic AMP ( cAMP ) and cAMP Receptor Protein ( CRP ) function in sucrose phosphorylase regulation ( Reid and Abratt 2005 ).
However, while a similar 3D framework has been proposed to account for this, there is no significant sequence similarity between these families : the cAMP receptors thus bear their own unique'7TM'signature.